Linear 1 3-diarylpropanoids
Medchemexpress LLC Isodecyl diphenyl phosphate | 29761-21-5 | MFCD00072254 | 99.0% | 390.45 | C22H31O4P | 10mg
Isodecyl diphenyl phosphate (IDPP) is a flame retardant IDPP has an ability to induce DNA damage and exertes S phase cell ratio-reducing effects in A549 cells[1]
Medchemexpress LLC Brepocitinib P-Tosylate | 2140301-96-6 | 99.99% | 561.60 | 10 MG
Brepocitinib P-Tosylate is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor with IC50s of 17 nM and 23 nM, respectively. It also inhibits JAK2 and JAK3 with IC50s of 77 nM and 6.49 μM, respectively. This product is intended for research use only.
- Potent dual JAK1 and TYK2 inhibitor
- Inhibits JAK2 and JAK3
- High purity of 99.99%
- Available in various quantities and forms
- Cited in multiple publications
- Undergoing various clinical trials
Medchemexpress LLC (±)-Naringenin | 67604-48-2 | MFCD00006844 | 99.83% | 272.26 | 1 ML
(±)-Naringenin is an orally available anti-inflammatory agent that regulates acute and chronic inflammation, and exhibits antioxidant, neuroprotective, liver-protective, and anti-cancer effects. It promotes vasodilation and protects against experimental colitis by inhibiting Toll-like receptor 4/NF-κB signaling, useful in studies of sepsis, fulminant hepatitis, fibrosis, and cancer. It appears as an off-white to light yellow solid.
- Regulates acute and chronic inflammation.
- Antioxidant, neuroprotective, liver-protective, and anti-cancer effects.
- Promotes vasodilation.
- Protects against experimental colitis.
- Useful in sepsis, hepatitis, fibrosis, and cancer research.
- Orally available.
Medchemexpress LLC (±)-Naringenin (Standard) | 67604-48-2 | 98.8% | 272.25 | 25 MG
(±)-Naringenin (Standard) is the analytical standard of (±)-Naringenin. It is a naturally-occurring flavonoid intended for research and analytical applications. It displays a vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.
- Used as a reference standard in qualitative, quantitative, and methodological research experiments.
- Commonly applied in techniques such as HPLC, GC, and MS.
- Appearance is a solid, white to light yellow.
- Chemical formula is C₁₅H₁₂O₅.
- Classified under flavonoids and phenols.
- Initial source is from other plant families.
TARGETMOL CHEMICALS INC 4 4 -Dimethoxychalcone 50MG
Also available in 1 mL, 25 mg, 100 mg and bulk. Please contact Fisher for quotes.4,4'-Dimethoxychalcone (4,4-Dimethoxychalcone) is a natural product. Purity 99.35%
Medchemexpress LLC (E)-Naringenin chalcone | 25515-46-2 | 100 MG
(E)-Naringenin chalcone is an orally active anti-allergic agent that also possesses antioxidant and anti-inflammatory activities. It can improve adipocyte functions and inhibits histamine release from rat peritoneal mast cells.
- Inhibits histamine release from rat peritoneal mast cells.
- Improves adipocyte functions by enhancing adiponectin production.
- Stimulates the activity of PPARγ in cells.
- Inhibits the production of TNF-alpha, MCP-1, and nitric oxide (NO) by LPS-stimulated macrophages.
- Exhibits anti-allergic effects in type I allergic mice.
- Suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells in allergic airway inflammatory mice.
Medchemexpress LLC Trans-chalcone | 614-47-1 | MFCD00003082 | 98.8% | 208.26 g/mol | C15H12O | 5g
trans-Chalcone isolated from Aronia melanocarpa skin is a biphenolic core structure of flavonoids precursor trans-Chalcone is a potent fatty acid synthase (FAS) and -amylase inhibitor trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7 trans-Chalcone has antifungal and anticancer activity[1][2][3]
Medchemexpress LLC 4'-Methoxychalcone | 959-23-9 | 99.8% | 10 G
4'-Methoxychalcone regulates adipocyte differentiation through PPARγ activation. It also modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity. This product is for research use only.
- Regulates adipocyte differentiation through PPARγ activation.
- Modulates the expression and secretion of various adipokines.
- Increases mRNA expression of adipogenic genes during differentiation.
- Reduces upregulated mRNA expression of inflammatory cytokines.
- Suitable for research use.
Apexbio Technology LLC Naringenin 480-41-1 10mM (in 1mL DMSO)
Naringenin (CAS 480-41-1) is a small-molecule inhibitor designed to modulate inflammatory and antiviral pathways thereby regulating cellular inflammatory responses and viral replication Naringenin exerts its biological activity primarily through inhibition of the NF- B pathway resulting in reduced inflammatory cytokine production Additionally it demonstrates antioxidative properties by scavenging reactive oxygen species (ROS) In in vitro studies naringenin exhibits inhibition of dengue virus replication with reported IC50 values ranging from approximately 52 64 M to 143 M depending on experimental conditions and viral strains Based on these pharmacological properties naringenin holds research potential in inflammation oxidative stress-related cellular models and dengue virus infection studies
Apexbio Technology LLC AKT inhibitor VIII(Synonyms: AKTi-1/2, Akt Inhibitor VIII, AKTi VIII, Akt kinase inhibitor VIII, Isozyme-selective AKT inhibitor VIII), 10mM (in 1mL DMSO), CAS: 612847-09-3.
AKT inhibitor VIII (CAS 612847-09-3) is a cell-permeable reversible inhibitor targeting Akt isoforms Akt1 Akt2 and Akt3 exhibiting IC50 values of 58 nM 210 nM and 2119 nM respectively It acts by suppressing Akt signaling as demonstrated by its ability to inhibit IGF-1-stimulated Akt phosphorylation and to reduce PRAS40 phosphorylation in PC12 cells In MCF-7 breast cancer cells AKT inhibitor VIII enhances the antiproliferative activity of furanodiene augmenting its effects on Akt/p-Akt downregulation and promoting PARP cleavage This compound is valuable for exploring Akt-dependent signaling pathways in oncology research and neuronal cell biology studies
Medchemexpress LLC 4'-Methoxychalcone | 959-23-9 | 99.8% | 50 G
4'-Methoxychalcone is a compound that regulates adipocyte differentiation through PPARγ activation. It modulates the expression and secretion of various adipokines in adipose tissue, which are involved in insulin sensitivity.
- Regulates adipocyte differentiation via PPARγ activation.
- Modulates adipokine expression and secretion.
- Increases mRNA expression of adipogenic genes during differentiation.
- Reduces upregulated mRNA expression of inflammatory markers in preadipocyte cells.
- Exhibits antiproliferative and cytotoxic activity against various human and mouse cell lines.